Due to an increase of diseases caused by oxidative stress, antioxidants have gained considerable interest for prevention and treatment skin cancer and potentially other non-communicable diseases. In this project, natural phenolic antioxidants will be synthesized using a bacterial enzyme. Small laccase (SLAC) is a robust enzyme with high catalytic activity. Protein design will be applied to improve its properties for applications such as synthesis of antioxidants and surface functionalisation.